Sleep is important for quality of life and optimal affect regulation. Sleep disturbances predict episodes of bipolar disorder and are among the most prominent correlates of mood episodes, and inadequate recovery in bipolar disorder. Sleep disturbance and circadian dysregulation are regarded as critical pathophysiological elements in bipolar disorder. Although the circadian system and the sleep system are potentially separable, they are interconnected. The serotonin and dopamine systems are implicated as the critical links between abnormalities in the sleep and circadian systems and affective functioning in bipolar disorder. Therefore, the effective treatment of sleep disturbances in bipolar disorder is a major clinical challenge. The development of adequate pharmacological and non-pharmacological treatment options for the regulation of sleep and circadian rhythms is essential for recovery and prevention of episodes in bipolar disorder.
In his presentation, Prof. Baune will review the evidence on the efficacy of quetiapine for the treatment of sleep disorders from randomized control trials and he will add experience from his clinical and research practice on this important topic. The presentation aims for an improved understanding as well as practical clinical recommendations for the treatment of sleep disorders in Bipolar Disorders.